Role of Insulin-Like Growth Factor Receptor 2 across Muscle Homeostasis: Implications for Treating Muscular Dystrophy.
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ABSTRACT:
SUBMITTER: Torrente Y
PROVIDER: S-EPMC7072799 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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Role of Insulin-Like Growth Factor Receptor 2 across Muscle Homeostasis: Implications for Treating Muscular Dystrophy.
Torrente Yvan Y Bella Pamela P Tripodi Luana L Villa Chiara C Farini Andrea A
Cells 20200214 2
The insulin-like growth factor 2 receptor (IGF2R) plays a major role in binding and regulating the circulating and tissue levels of the mitogenic peptide insulin-like growth factor 2 (IGF2). IGF2/IGF2R interaction influences cell growth, survival, and migration in normal tissue development, and the deregulation of IGF2R expression has been associated with growth-related disease and cancer. IGF2R overexpression has been implicated in heart and muscle disease progression. Recent research findings ...[more]
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