Ontology highlight
ABSTRACT:
SUBMITTER: Petersen M
PROVIDER: S-EPMC7072805 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Petersen Maj M Gandhi Prafull S PS Buchardt Jens J Alanentalo Tomas T Fels Johannes Josef JJ Johansen Nils Langeland NL Helding-Kvist Peter P Vad Knud K Thygesen Peter P
International journal of molecular sciences 20200211 4
Somapacitan is a long-acting, once-weekly, albumin-binding growth hormone (GH) derivative. The reversible albumin-binding properties leads to prolonged circulation half-life. Here, we investigated and compared somapacitan with human GH on downstream receptor signaling in primary hepatocytes and hepatocellular models and using isothermal titration calorimetry to characterize receptor binding of somapacitan in the presence or absence of human serum albumin (HSA). With non-invasive fluorescence ima ...[more]