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Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy.

ABSTRACT: Improved understanding of microRNA expression and function in cancer has revealed a range of microRNAs that negatively regulate many oncogenic pathways, thus representing potent tumor suppressors. Therapeutic targeting of the expression of these microRNAs to the site of tumors and metastases provides a promising avenue for cancer therapy. To overcome challenges associated with microRNA degradation, transient expression and poor targeting, novel nanoparticles are being developed and employed to shield microRNAs for tumor-targeted delivery. This review focuses on studies describing a variety of both natural and synthetic nanoparticle delivery vehicles that have been engineered for tumor-targeted delivery of tumor suppressor microRNAs in vivo.

SUBMITTER: O'Neill CP

PROVIDER: S-EPMC7072816 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy.

O'Neill Clodagh P CP Dwyer Róisín M RM

Cells 20200224 2

Improved understanding of microRNA expression and function in cancer has revealed a range of microRNAs that negatively regulate many oncogenic pathways, thus representing potent tumor suppressors. Therapeutic targeting of the expression of these microRNAs to the site of tumors and metastases provides a promising avenue for cancer therapy. To overcome challenges associated with microRNA degradation, transient expression and poor targeting, novel nanoparticles are being developed and employed to s ...[more]

PMID: 32102476

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