Ontology highlight
ABSTRACT:
SUBMITTER: Mondelo-Macia P
PROVIDER: S-EPMC7072825 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Mondelo-Macía Patricia P Rodríguez-López Carmela C Valiña Laura L Aguín Santiago S León-Mateos Luis L García-González Jorge J Abalo Alicia A Rapado-González Oscar O Suárez-Cunqueiro Mercedes M Díaz-Lagares Angel A Curiel Teresa T Calabuig-Fariñas Silvia S Azkárate Aitor A Obrador-Hevia Antònia A Abdulkader Ihab I Muinelo-Romay Laura L Diaz-Peña Roberto R López-López Rafael R
Cells 20200224 2
MET alterations may provide a potential biomarker to evaluate patients who will benefit from treatment with MET inhibitors. Therefore, the purpose of the present study is to investigate the utility of a liquid biopsy-based strategy to assess MET alterations in cancer patients. We analyzed <i>MET</i> amplification in circulating free DNA (cfDNA) from 174 patients with cancer and 49 healthy controls and demonstrated the accuracy of the analysis to detect its alteration in patients. Importantly, a ...[more]