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Novel Basic Science Insights to Improve the Management of Heart Failure: Review of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology.

ABSTRACT: Despite important advances in diagnosis and treatment, heart failure (HF) remains a syndrome with substantial morbidity and dismal prognosis. Although implementation and optimization of existing technologies and drugs may lead to better management of HF, new or alternative strategies are desirable. In this regard, basic science is expected to give fundamental inputs, by expanding the knowledge of the pathways underlying HF development and progression, identifying approaches that may improve HF detection and prognostic stratification, and finding novel treatments. Here, we discuss recent basic science insights that encompass major areas of translational research in HF and have high potential clinical impact.

SUBMITTER: Ameri P 

PROVIDER: S-EPMC7072832 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Novel Basic Science Insights to Improve the Management of Heart Failure: Review of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology.

Ameri Pietro P   Schiattarella Gabriele Giacomo GG   Crotti Lia L   Torchio Margherita M   Bertero Edoardo E   Rodolico Daniele D   Forte Maurizio M   Di Mauro Vittoria V   Paolillo Roberta R   Chimenti Cristina C   Torella Daniele D   Catalucci Daniele D   Sciarretta Sebastiano S   Basso Cristina C   Indolfi Ciro C   Perrino Cinzia C  

International journal of molecular sciences 20200211 4

Despite important advances in diagnosis and treatment, heart failure (HF) remains a syndrome with substantial morbidity and dismal prognosis. Although implementation and optimization of existing technologies and drugs may lead to better management of HF, new or alternative strategies are desirable. In this regard, basic science is expected to give fundamental inputs, by expanding the knowledge of the pathways underlying HF development and progression, identifying approaches that may improve HF d  ...[more]

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