Ontology highlight
ABSTRACT:
SUBMITTER: Di Cosimo S
PROVIDER: S-EPMC7073028 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Di Cosimo Serena S Appierto Valentina V Pizzamiglio Sara S Silvestri Marco M Baselga José J Piccart Martine M Huober Jens J Izquierdo Miguel M de la Pena Lorena L Hilbers Florentine S FS de Azambuja Evandro E Untch Michael M Pusztai Lajos L Pritchard Kathleen K Nuciforo Paolo P Vincent-Salomon Anne A Symmans Fraser F Apolone Giovanni G de Braud Filippo G FG Iorio Marilena V MV Verderio Paolo P Daidone Maria Grazia MG
International journal of molecular sciences 20200218 4
Circulating microRNA (ct-miRNAs) are able to identify patients with differential response to HER2-targeted therapy. However, their dynamics are largely unknown. We assessed 752 miRNAs from 52 NeoALTTO patients with plasma pairs prior and two weeks after trastuzumab. Increased levels of ct-miR-148a-3p and ct-miR-374a-5p were significantly associated with pathological complete response (pCR) (<i>p</i> = 0.008 and 0.048, respectively). At a threshold ≥ the upper limit of the 95%CI of the mean diffe ...[more]