Ontology highlight
ABSTRACT:
SUBMITTER: Gu Y
PROVIDER: S-EPMC7073110 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Gu Yuchen Y Moroy Gautier G Paul Jean-Louis JL Rebillat Anne-Sophie AS Dierssen Mara M de la Torre Rafael R Cieuta-Walti Cécile C Dairou Julien J Janel Nathalie N
International journal of molecular sciences 20200219 4
Epigallocatechin gallate (EGCG) is an inhibitor of DYRK1A, a serine/threonine kinase considered to be a major contributor of cognitive dysfunctions in Down syndrome (DS). Two clinical trials in adult patients with DS have shown the safety and efficacy to improve cognitive phenotypes using commercial green tea extract containing EGCG (45% content). In the present study, we performed a preclinical study using FontUp<sup>®</sup>, a new nutritional supplement with a chocolate taste specifically form ...[more]