Ontology highlight
ABSTRACT:
SUBMITTER: Lim H
PROVIDER: S-EPMC7073460 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Lim Hyoungsub H Lee Jaesung J You Byunghyun B Oh Jae Hoon JH Mok Hyuck Jun HJ Kim Yoo Sung YS Yoon Bo-Eun BE Kim Byung Gon BG Back Seung Keun SK Park Jong-Sang JS Kim Kwang Pyo KP Schnaar Ronald L RL Lee Sung Joong SJ
The EMBO journal 20200206 6
Spinal cord microglia contribute to nerve injury-induced neuropathic pain. We have previously demonstrated that toll-like receptor 2 (TLR2) signaling is critical for nerve injury-induced activation of spinal cord microglia, but the responsible endogenous TLR2 agonist has not been identified. Here, we show that nerve injury-induced upregulation of sialyltransferase St3gal2 in sensory neurons leads to an increase in expression of the sialylated glycosphingolipid, GT1b. GT1b ganglioside is axonally ...[more]