Ontology highlight
ABSTRACT:
SUBMITTER: Hoffmann K
PROVIDER: S-EPMC7073464 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Hoffmann Karen K Berger Hilmar H Kulbe Hagen H Thillainadarasan Sukanija S Mollenkopf Hans-Joachim HJ Zemojtel Tomasz T Taube Eliane E Darb-Esfahani Silvia S Mangler Mandy M Sehouli Jalid J Chekerov Radoslav R Braicu Elena I EI Meyer Thomas F TF Kessler Mirjana M
The EMBO journal 20200203 6
High-grade serous ovarian cancer (HGSOC) likely originates from the fallopian tube (FT) epithelium. Here, we established 15 organoid lines from HGSOC primary tumor deposits that closely match the mutational profile and phenotype of the parental tumor. We found that Wnt pathway activation leads to growth arrest of these cancer organoids. Moreover, active BMP signaling is almost always required for the generation of HGSOC organoids, while healthy fallopian tube organoids depend on BMP suppression ...[more]