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Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae.


ABSTRACT: Chemical investigation of secondary metabolites from the endophytic fungus Pseudopestalotiopsis theae led to the isolation of eighteen new polyketide derivatives, pestalotheols I-Q (1-9) and cytosporins O-W (15-23), together with eight known analogs (10-14 and 24-26). The structures of the new compounds were elucidated by HRMS and 1D and 2D NMR data, as well as by comparison with literature data. Modified Mosher's method was applied to determine the absolute configuration of some compounds. Compound 23 showed significant cytotoxicity against the mouse lymphoma cell line L5178Y with an IC50 value of 3.0 ?M. Furthermore, compounds 22 and 23 showed moderate antibacterial activity against drug-resistant Acinetobacter baumannii (ATCC BAA-1605) in combination with sublethal colistin concentrations.

SUBMITTER: Yu X 

PROVIDER: S-EPMC7073511 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Polyketide Derivatives from Mangrove Derived Endophytic Fungus <i>Pseudopestalotiopsis theae</i>.

Yu Xiaoqin X   Müller Werner E G WEG   Meier Dieter D   Kalscheuer Rainer R   Guo Zhiyong Z   Zou Kun K   Umeokoli Blessing O BO   Liu Zhen Z   Proksch Peter P  

Marine drugs 20200223 2


Chemical investigation of secondary metabolites from the endophytic fungus <i>Pseudopestalotiopsis theae</i> led to the isolation of eighteen new polyketide derivatives, pestalotheols I-Q (<b>1</b>-<b>9</b>) and cytosporins O-W (<b>15</b>-<b>23</b>), together with eight known analogs (<b>10</b>-<b>14</b> and <b>24</b>-<b>26</b>). The structures of the new compounds were elucidated by HRMS and 1D and 2D NMR data, as well as by comparison with literature data. Modified Mosher's method was applied  ...[more]

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