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Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis.

ABSTRACT: OBJECTIVE:Investigate if there is an association between apical periodontitis and diabetes mellitus. MATERIAL AND METHODS:A bibliographic search was performed on Medline/PubMed, Scopus and Cochrane databases using the keywords apical periodontitis and diabetes mellitus. Published papers written in English and performed on animals or humans were included. Meta-analysis was performed using the OpenMeta (analyst) tool for the statistical analysis. The variables analyzed were the prevalence of Apical Periodontitis (AP) among teeth and patients with Diabetes Mellitus (DM). RESULTS:Of the total studies found, only 21 met the inclusion criteria. Ten clinical studies on animals, ten studies on humans and a systematic review were included. Meta-analysis shows that the prevalence of teeth with apical periodontitis among patients with diabetes mellitus has an odds ratio of 1.166 corresponding to 507 teeth with AP + DM and 534 teeth with AP without DM. The prevalence of patients with AP and DM shows an odds ratio of 1.552 where 91 patients had AP + DM and 582 patients AP without DM. CONCLUSION:Scientific evidence suggests that there could be a common physiopathological factor between apical periodontitis and diabetes mellitus but more prospective studies are needed to investigate the association between these two diseases.

SUBMITTER: Perez-Losada FL

PROVIDER: S-EPMC7074097 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis.

Pérez-Losada Flor de Liz FL Estrugo-Devesa Albert A Castellanos-Cosano Lissett L Segura-Egea Juan José JJ López-López José J Velasco-Ortega Eugenio E

Journal of clinical medicine 20200217 2

<h4>Objective</h4>Investigate if there is an association between apical periodontitis and diabetes mellitus.<h4>Material and methods</h4>A bibliographic search was performed on Medline/PubMed, Scopus and Cochrane databases using the keywords apical periodontitis and diabetes mellitus. Published papers written in English and performed on animals or humans were included. Meta-analysis was performed using the OpenMeta (analyst) tool for the statistical analysis. The variables analyzed were the prev ...[more]

PMID: 32079175

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Dataset Information

Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis.

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Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis.

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