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Variable Responses to Corneal Grafts: Insights from Immunology and Systems Biology.


ABSTRACT: Corneal grafts interact with their hosts via complex immunobiological processes that sometimes lead to graft failure. Prediction of graft failure is often a tedious task due to the genetic and nongenetic heterogeneity of patients. As in other areas of medicine, a reliable prediction method would impact therapeutic decision-making in corneal transplantation. Valuable insights into the clinically observed heterogeneity of host responses to corneal grafts have emerged from multidisciplinary approaches, including genomics analyses, mechanical studies, immunobiology, and theoretical modeling. Here, we review the emerging concepts, tools, and new biomarkers that may allow for the prediction of graft survival.

SUBMITTER: Di Zazzo A 

PROVIDER: S-EPMC7074162 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Variable Responses to Corneal Grafts: Insights from Immunology and Systems Biology.

Di Zazzo Antonio A   Lee Sang-Mok SM   Sung Jaemyoung J   Niutta Matteo M   Coassin Marco M   Mashaghi Alireza A   Inomata Takenori T  

Journal of clinical medicine 20200221 2


Corneal grafts interact with their hosts via complex immunobiological processes that sometimes lead to graft failure. Prediction of graft failure is often a tedious task due to the genetic and nongenetic heterogeneity of patients. As in other areas of medicine, a reliable prediction method would impact therapeutic decision-making in corneal transplantation. Valuable insights into the clinically observed heterogeneity of host responses to corneal grafts have emerged from multidisciplinary approac  ...[more]

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