Ontology highlight
ABSTRACT:
SUBMITTER: Cheng AV
PROVIDER: S-EPMC7074213 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Cheng Ana V AV Kim Wooseong W Escobar Iliana E IE Mylonakis Eleftherios E Wuest William M WM
ACS medicinal chemistry letters 20190717 3
We previously reported the antibacterial activity of CD437, a known antitumor compound. It proved to be a potent antimicrobial agent effective against both growing and persister cells of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). Herein, we report the synthesis of a panel of analogs and their effect on both MRSA and cancer cells. The hydrophobic group of the parent compound was varied in steric bulk, and lipid-mimicking analogs were tested. Biological assessment confirmed that th ...[more]