Cas3 Protein-A Review of a Multi-Tasking Machine.
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ABSTRACT:
SUBMITTER: He L
PROVIDER: S-EPMC7074321 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Cas3 Protein-A Review of a Multi-Tasking Machine.
He Liu L St John James Michael M Radovcic Marin M Ivancic-Bace Ivana I Bolt Edward L EL
Genes 20200218 2
Cas3 has essential functions in CRISPR immunity but its other activities and roles, in vitro and in cells, are less widely known. We offer a concise review of the latest understanding and questions arising from studies of Cas3 mechanism during CRISPR immunity, and highlight recent attempts at using Cas3 for genetic editing. We then spotlight involvement of Cas3 in other aspects of cell biology, for which understanding is lacking-these focus on CRISPR systems as regulators of cellular processes i ...[more]
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