Ontology highlight
ABSTRACT:
SUBMITTER: Matellan L
PROVIDER: S-EPMC7074328 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Matellán Laura L Monje-Casas Fernando F
Genes 20200212 2
In order to preserve genome integrity and their ploidy, cells must ensure that the duplicated genome has been faithfully replicated and evenly distributed before they complete their division by mitosis. To this end, cells have developed highly elaborated checkpoints that halt mitotic progression when problems in DNA integrity or chromosome segregation arise, providing them with time to fix these issues before advancing further into the cell cycle. Remarkably, exit from mitosis constitutes a key ...[more]