Identification of Clonality through Genomic Profile Analysis in Multiple Lung Cancers.

ABSTRACT: In cases of multiple lung cancers, individual tumors may represent either a primary lung cancer or both primary and metastatic lung cancers. In this study, we investigated the differences between clinical/histopathological and genomic diagnoses to determine whether they are primary or metastatic. 37 patients with multiple lung cancers were enrolled in this study. Tumor cells were selected from tissue samples using laser capture microdissection. DNA was extracted from those cells and subjected to targeted deep sequencing. In multicentric primary lung cancers, the driver mutation profile was mutually exclusive among the individual tumors, while it was consistent between metastasized tumors and the primary lesion. In 11 patients (29.7%), discrepancies were observed between genomic and clinica

SUBMITTER: Higuchi R 

PROVIDER: S-EPMC7074554 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature