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Review on Microbubbles and Microdroplets Flowing through Microfluidic Geometrical Elements.

ABSTRACT: Two-phase flows are found in several industrial systems/applications, including boilers and condensers, which are used in power generation or refrigeration, steam generators, oil/gas extraction wells and refineries, flame stabilizers, safety valves, among many others. The structure of these flows is complex, and it is largely governed by the extent of interphase interactions. In the last two decades, due to a large development of microfabrication technologies, many microstructured devices involving several elements (constrictions, contractions, expansions, obstacles, or T-junctions) have been designed and manufactured. The pursuit for innovation in two-phase flows in these elements require an understanding and control of the behaviour of bubble/droplet flow. The need to systematize the most relevant studies that involve these issues constitutes the motivation for this review. In the present work, literature addressing gas-liquid and liquid-liquid flows, with Newtonian and non-Newtonian fluids, and covering theoretical, experimental, and numerical approaches, is reviewed. Particular focus is given to the deformation, coalescence, and breakup mechanisms when bubbles and droplets pass through the aforementioned microfluidic elements.

SUBMITTER: Cerdeira ATS

PROVIDER: S-EPMC7074625 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Review on Microbubbles and Microdroplets Flowing through Microfluidic Geometrical Elements.

Cerdeira Ana T S ATS Campos João B L M JBLM Miranda João M JM Araújo José D P JDP

Micromachines 20200215 2

Two-phase flows are found in several industrial systems/applications, including boilers and condensers, which are used in power generation or refrigeration, steam generators, oil/gas extraction wells and refineries, flame stabilizers, safety valves, among many others. The structure of these flows is complex, and it is largely governed by the extent of interphase interactions. In the last two decades, due to a large development of microfabrication technologies, many microstructured devices involv ...[more]

PMID: 32075302

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Project description:The loss of the red blood cells (RBCs) deformability is related with many human diseases, such as malaria, hereditary spherocytosis, sickle cell disease, or renal diseases. Hence, during the last years, a variety of technologies have been proposed to gain insights into the factors affecting the RBCs deformability and their possible direct association with several blood pathologies. In this work, we present a simple microfluidic tool that provides the assessment of motions and deformations of RBCs of end-stage kidney disease (ESKD) patients, under a well-controlled microenvironment. All of the flow studies were performed within a hyperbolic converging microchannels where single-cell deformability was assessed under a controlled homogeneous extensional flow field. By using a passive microfluidic device, RBCs passing through a hyperbolic-shaped contraction were measured by a high-speed video microscopy system, and the velocities and deformability ratios (DR) calculated. Blood samples from 27 individuals, including seven healthy controls and 20 having ESKD with or without diabetes, were analysed. The obtained data indicates that the proposed device is able to detect changes in DR of the RBCs, allowing for distinguishing the samples from the healthy controls and the patients. Overall, the deformability of ESKD patients with and without diabetes type II is lower in comparison with the RBCs from the healthy controls, with this difference being more evident for the group of ESKD patients with diabetes. RBCs from ESKD patients without diabetes elongate on average 8% less, within the hyperbolic contraction, as compared to healthy controls; whereas, RBCs from ESKD patients with diabetes elongate on average 14% less than the healthy controls. The proposed strategy can be easily transformed into a simple and inexpensive diagnostic microfluidic system to assess blood cells deformability due to the huge progress in image processing and high-speed microvisualization technology.

Dataset Information

Review on Microbubbles and Microdroplets Flowing through Microfluidic Geometrical Elements.

Publications

Review on Microbubbles and Microdroplets Flowing through Microfluidic Geometrical Elements.

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