Ontology highlight
ABSTRACT:
SUBMITTER: Yamada N
PROVIDER: S-EPMC7074916 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Yamada Naomi N Kuntala Prashant Kumar PK Pugh B Franklin BF Mahony Shaun S
Journal of computational biology : a journal of computational molecular cell biology 20200205 3
Regulatory proteins can employ multiple direct and indirect modes of interaction with the genome. The ChIP-exo mixture model (ChExMix) provides a principled approach to detecting multiple protein-DNA interaction modes in a single ChIP-exo experiment. ChExMix discovers and characterizes binding event subtypes in ChIP-exo data by leveraging both protein-DNA cross-linking signatures and DNA motifs. In this study, we present a summary of the major features and applications of ChExMix. We demonstrate ...[more]