Polyol-Made Luminescent and Superparamagnetic ?-NaY0.8Eu0.2F4@?-Fe2O3 Core-Satellites Nanoparticles for Dual Magnetic Resonance and Optical Imaging.

ABSTRACT: Red luminescent and superparamagnetic ?-NaY0.8Eu0.2F4@?-Fe2O3 nanoparticles, made of a 70 nm-sized ?-NaY0.8Eu0.2F4 single crystal core decorated by a 10 nm-thick polycrystalline and discontinuous ?-Fe2O3 shell, have been synthesized by the polyol process. Functionalized with citrate ligands they show a good colloidal stability in water making them valuable for dual magnetic resonance and optical imaging or image-guided therapy. They exhibit a relatively high transverse relaxivity r2 = 42.3 mM-1·s-1 in water at 37 °C, for an applied static magnetic field of 1.41 T, close to the field of 1.5 T applied in clinics, as they exhibit a red emission by two-photon excited fluorescence microscopy. Finally, when brought into contact with healthy human foreskin fibroblast cells (BJH), for doses as high as 50 µg·mL-1 and incubation time as long as 72 h, they do not show evidence of any accurate cytotoxicity, highlighting their biomedical applicative potential.

SUBMITTER: Mnasri W 

PROVIDER: S-EPMC7075321 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature