Dataset Information

Intrauterine exposure to perfluorinated compounds and overweight at age 4: A case-control study.

ABSTRACT: AIMS:The aims were to investigate the association between maternal serum levels of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS) and perfluorononanoic acid (PFNA) in early pregnancy and overweight in the child at 4 years and to assess potential heterogeneity in exposure effect between strata with different levels of other risk factors for overweight. METHODS:We used a case-control design and included 354 cases (ISO-BMI ? 18 kg/m2) and 2 controls per case (ISO-BMI ?17 kg/m2) from child health care centers in Malmö, Sweden. Controls were selected stratified on risk scores for overweight in a propensity score framework. Maternal serum levels were analyzed in biobanked samples collected by routine around gestational week 14. Logistic regression was used to estimate odds ratios between quartiles of maternal serum levels and child overweight at age 4. RESULTS:There were no consistent monotonic exposure-response relationships. We found some significant odds ratios in specific quartiles but these were regarded as spurious findings. The absence of an effect was consistent over risk strata. CONCLUSIONS:We did not find evidence of an association between maternal serum levels of PFOS, PFOA, PFHxS and PFNA in early pregnancy and child overweight at age 4. The level of other risk factors for overweight did not affect children's susceptibility to prenatal PFAS exposure.

SUBMITTER: Martinsson M

PROVIDER: S-EPMC7075550 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Intrauterine exposure to perfluorinated compounds and overweight at age 4: A case-control study.

Martinsson Matilda M Nielsen Christel C Björk Jonas J Rylander Lars L Malmqvist Ebba E Lindh Christian C Rignell-Hydbom Anna A

PloS one 20200316 3

<h4>Aims</h4>The aims were to investigate the association between maternal serum levels of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS) and perfluorononanoic acid (PFNA) in early pregnancy and overweight in the child at 4 years and to assess potential heterogeneity in exposure effect between strata with different levels of other risk factors for overweight.<h4>Methods</h4>We used a case-control design and included 354 cases (ISO-BMI ≥ 18 kg/m ...[more]

PMID: 32176721

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Project description:ObjectiveTo identify specific major congenital malformations associated with use of carbamazepine in the first trimester of pregnancy.DesignA review of all published cohort studies to identify key indications and a population based case-control study to test these indications.SettingReview of PubMed, Web of Science, and Embase for papers about carbamazepine exposure in the first trimester of pregnancy and specific malformations, and the EUROCAT Antiepileptic Study Database, including data from 19 European population based congenital anomaly registries, 1995-2005.ParticipantsThe literature review covered eight cohort studies of 2680 pregnancies with carbamazepine monotherapy exposure, and the EUROCAT dataset included 98 075 registrations of malformations covering over 3.8 million births.Main outcome measuresOverall prevalence for a major congenital malformation after exposure to carbamazepine monotherapy in the first trimester. Odds ratios for malformations with exposure to carbamazepine among cases (five types of malformation identified in the literature review) compared with two groups of controls: other non-chromosomal registrations of malformations and chromosomal syndromes.ResultsThe literature review yielded an overall prevalence for a major congenital malformation of 3.3% (95% confidence interval 2.7 to 4.2) after exposure to carbamazepine monotherapy in the first trimester. In 131 registrations of malformations, the fetus had been exposed to carbamazepine monotherapy. Spina bifida was the only specific major congenital malformation significantly associated with exposure to carbamazepine monotherapy (odds ratio 2.6 (95% confidence interval 1.2 to 5.3) compared with no antiepileptic drug), but the risk was smaller for carbamazepine than for valproic acid (0.2, 0.1 to 0.6). There was no evidence for an association with total anomalous pulmonary venous return (no cases with carbamazepine exposure), cleft lip (with or without palate) (0.2, 0.0 to 1.3), diaphragmatic hernia (0.9, 0.1 to 6.6), or hypospadias (0.7, 0.3 to 1.6) compared with no exposure to antiepileptic drugs. Further exploratory analysis suggested a higher risk of single ventricle and atrioventricular septal defect.ConclusionCarbamazepine teratogenicity is relatively specific to spina bifida, though the risk is less than with valproic acid. Despite the large dataset, there was not enough power to detect moderate risks for some rare major congenital malformations.

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Dataset Information

Intrauterine exposure to perfluorinated compounds and overweight at age 4: A case-control study.

Publications

Intrauterine exposure to perfluorinated compounds and overweight at age 4: A case-control study.

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