Quantitative phase imaging of stromal prognostic markers in pancreatic ductal adenocarcinoma.
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ABSTRACT:
SUBMITTER: Fanous M
PROVIDER: S-EPMC7075600 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Quantitative phase imaging of stromal prognostic markers in pancreatic ductal adenocarcinoma.
Fanous Michael M Keikhosravi Adib A Kajdacsy-Balla Andre A Eliceiri Kevin W KW Popescu Gabriel G
Biomedical optics express 20200212 3
New quantitative prognostic markers are needed for improved pancreatic ductal adenocarcinoma (PDAC) prognosis. Second harmonic generation microscopy has been used to show that collagen fiber alignment in PDAC is a negative prognostic factor. In this work, a series of PDAC and normal adjacent tissue (NAT) biopsies were imaged with spatial light interference microscopy (SLIM). Quantitative analysis performed on the biopsy SLIM images show that PDAC fiber structures have lower alignment per unit le ...[more]
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