Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo.

ABSTRACT: Though neurotransmitters are essential elements in neuronal signal transduction, techniques for in vivo analysis are still limited. Here, we describe an organic electrochemical transistor array (OECT-array) technique for monitoring catecholamine neurotransmitters (CA-NTs) in rat brains. The OECT-array is an active sensor with intrinsic amplification capability, allowing real-time and direct readout of transient CA-NT release with a sensitivity of nanomolar range and a temporal resolution of several milliseconds. The device has a working voltage lower than half of that typically used in a prevalent cyclic voltammetry measurement, and operates continuously in vivo for hours without significant signal drift, which is inaccessible for existing methods. With the OECT-array,

SUBMITTER: Xie K 

PROVIDER: S-EPMC7075691 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature