Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC7076256 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Liu Liu L Yu Le L Zeng Cheng C Long Hua H Duan Guangjie G Yin Guobing G Dai Xiaotian X Lin Zhenghong Z
Molecular and cellular biology 20200316 7
The NAD-dependent histone deacetylase sirtuin 2 (SIRT2) plays critical roles in mitosis and cell cycle progression and recently was shown to suppress tumor growth and to be downregulated in several types of cancers. However, the underlying mechanism of SIRT2 downregulation remains unknown. In this study, using bioinformatics, gene expression profiling, protein overexpression approaches, and cell migration assays, we showed that E3 ubiquitin ligase 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) ...[more]