Ontology highlight
ABSTRACT:
SUBMITTER: Simancas-Herbada R
PROVIDER: S-EPMC7076391 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Simancas-Herbada Rebeca R Fernández-Carballido Ana A Aparicio-Blanco Juan J Slowing Karla K Rubio-Retama Jorge J López-Cabarcos Enrique E Torres-Suárez Ana-Isabel AI
Pharmaceutics 20200219 2
The potential of a new poly(magnesium acrylate) hydrogel (PAMgA) as a pharmaceutical excipient for the elaboration of matrix tablets for the extended release of highly hydrophilic drugs was evaluated. The polymer was synthetized with two different crosslinking degrees that were characterized by FTIR and DSC. Their acute oral toxicity was determined in a mouse model, showing no toxicity at doses up to 10 g/kg. Matrix tablets were prepared using metformin hydrochloride as a model drug and the mech ...[more]