Ontology highlight
ABSTRACT:
SUBMITTER: C de S L Oliveira AL
PROVIDER: S-EPMC7076533 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
C de S L Oliveira Ana Luiza AL Araújo Júnior Raimundo Fernandes de RF Gomes de Carvalho Thaís T B Chan Alan A Schomann Timo T Tamburini Filippo F de Geus-Oei Lioe-Fee LF J Cruz Luis L
Pharmaceutics 20200223 2
Apoptosis signaling pathways, drug resistance, and metastasis are important targets to develop new cancer treatments. We developed cholesterol-coated Poly(d,l-Lactide-<i>co</i>-Glycolic Acid) (PLGA) nanoparticles for effective encapsulation and delivery of retinoic acid and oxaliplatin to analyze their antitumor activity in colorectal cancer. The cell viability and proliferation of tumoral cells lines (CT-26 and SW-480) decreased when compared to control in vitro after treatment with the nanopar ...[more]