The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani.
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ABSTRACT:
SUBMITTER: Wall RJ
PROVIDER: S-EPMC7076694 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
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The Q<sub>i</sub> Site of Cytochrome <i>b</i> is a Promiscuous Drug Target in <i>Trypanosoma cruzi</i> and <i>Leishmania donovani</i>.
Wall Richard J RJ Carvalho Sandra S Milne Rachel R Bueren-Calabuig Juan A JA Moniz Sonia S Cantizani-Perez Juan J MacLean Lorna L Kessler Albane A Cotillo Ignacio I Sastry Lalitha L Manthri Sujatha S Patterson Stephen S Zuccotto Fabio F Thompson Stephen S Martin Julio J Marco Maria M Miles Timothy J TJ De Rycker Manu M Thomas Michael G MG Fairlamb Alan H AH Gilbert Ian H IH Wyllie Susan S
ACS infectious diseases 20200130 3
Available treatments for Chagas' disease and visceral leishmaniasis are inadequate, and there is a pressing need for new therapeutics. Drug discovery efforts for both diseases principally rely upon phenotypic screening. However, the optimization of phenotypically active compounds is hindered by a lack of information regarding their molecular target(s). To combat this issue we initiate target deconvolution studies at an early stage. Here, we describe comprehensive genetic and biochemical studies ...[more]
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