Shiga Toxin-Associated Hemolytic Uremic Syndrome: A Narrative Review.

ABSTRACT: The severity of human infection by one of the many Shiga toxin-producing Escherichia coli (STEC) is determined by a number of factors: the bacterial genome, the capacity of human societies to prevent foodborne epidemics, the medical condition of infected patients (in particular their hydration status, often compromised by severe diarrhea), and by our capacity to devise new therapeutic approaches, most specifically to combat the bacterial virulence factors, as opposed to our current strategies that essentially aim to palliate organ deficiencies. The last major outbreak in 2011 in Germany, which killed more than 50 people in Europe, was evidence that an effective treatment was still lacking. Herein, we review the current knowledge of STEC virulence, how societies organize the preventi

SUBMITTER: Joseph A 

PROVIDER: S-EPMC7076748 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature