Ontology highlight
ABSTRACT:
SUBMITTER: Anderson EM
PROVIDER: S-EPMC7077288 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Anderson Elizabeth M EM Simonetti Francesco R FR Gorelick Robert J RJ Hill Shawn S Gouzoulis Monica A MA Bell Jennifer J Rehm Catherine C Pérez Liliana L Boritz Eli E Wu Xiaolin X Wells Daria D Hughes Stephen H SH Rao Venigalla V Coffin John M JM Kearney Mary F MF Maldarelli Frank F
Viruses 20200125 2
Combination antiretroviral therapy (cART) controls but does not eradicate HIV infection; HIV persistence is the principal obstacle to curing infections. The proportion of defective proviruses increases during cART, but the dynamics of this process are not well understood, and a quantitative analysis of how the proviral landscape is reshaped after cART is initiated is critical to understanding how HIV persists. Here, we studied longitudinal samples from HIV infected individuals undergoing long te ...[more]