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A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display.

ABSTRACT: Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein-protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing ?-methyl cysteine and cyclized with m-dibromoxylene. We focus on development of a peptide binder to the HPV16 E2 protein.

SUBMITTER: Iqbal ES 

PROVIDER: S-EPMC7077329 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display.

Iqbal Emil S ES   Richardson Stacie L SL   Abrigo Nicolas A NA   Dods Kara K KK   Osorio Franco H Estheban HE   Gerrish Heather S HS   Kotapati Hari Kiran HK   Morgan Iain M IM   Masterson Douglas S DS   Hartman Matthew C T MCT  

Chemical communications (Cambridge, England) 20190710 61

Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein-protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized with m-dibromoxylene. We focus on development of a peptide binder to the HPV16 E2 protein. ...[more]

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