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Electrospinning and Post-Spun Chain Conformations of Synthetic, Hydrophobic Poly(?-amino acid)s.

ABSTRACT: Electrospinning and post-spun conformations of hydrophobic poly(?-amino acid)s are described in this study. The poly(?-amino acid)s, poly(Gly), poly(L-Ala), poly(L-Val), and poly(L-Leu) were synthesized via corresponding N-carboxy-a-amino acid anhydrides. The average molecular weight and degree of polymerization of these polymers were determined by N-terminus labeling using 2,4-dinitrofluorobenzene and by viscometry in the case of poly(Gly). These poly(?-amino acid)s were electrospun from trifluoroacetic acid or trifluoroacetic acid/dichloromethane solutions. The FT-IR spectroscopy and wide-angle X-ray diffraction indicated that the electrospun poly(L-Ala) and poly(L-Leu) fibers predominantly adopts ?-helical structure, whereas poly(L-Val) and poly(Gly) fibers exhibited mainly ?-strand and random coil structures, respectively.

SUBMITTER: Devarayan K

PROVIDER: S-EPMC7077440 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Electrospinning and Post-Spun Chain Conformations of Synthetic, Hydrophobic Poly(α-amino acid)s.

Devarayan Kesavan K Nakagami Souta S Suzuki Shuichi S Yuki Ichiro I Ohkawa Kousaku K

Polymers 20200204 2

Electrospinning and post-spun conformations of hydrophobic poly(α-amino acid)s are described in this study. The poly(α-amino acid)s, poly(Gly), poly(L-Ala), poly(L-Val), and poly(L-Leu) were synthesized via corresponding N-carboxy-a-amino acid anhydrides. The average molecular weight and degree of polymerization of these polymers were determined by N-terminus labeling using 2,4-dinitrofluorobenzene and by viscometry in the case of poly(Gly). These poly(α ...[more]

PMID: 32033154

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