Ontology highlight
ABSTRACT:
SUBMITTER: Lai Y
PROVIDER: S-EPMC7077530 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Lai Yuexing Y Xu Ping P Wang Jing J Xu Kai K Wang Lin L Meng Yuchen Y
Journal of cellular and molecular medicine 20200124 5
Emerging evidence has revealed that dysregulation of lncRNA is associated with the initiation and progression of cancer. However, the function of these lncRNAs in cancer remains largely unexplored. Here, we reported that AFDN-DT, an lncRNA that is repressed in gastric cancers (GC), functions as a tumour suppressor by inhibiting cell growth and metastasis through transcriptional repression of genes involved in metastasis. Using in vitro and in vivo models, we demonstrated that overexpression of A ...[more]