Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC7077597 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Yang Yuxin Y Song Shuting S Meng Qiuyu Q Wang Liyan L Li Xiaonan X Xie Sijie S Chen Yingjie Y Jiang Xiaoxue X Wang Chen C Lu Yanan Y Xin Xiaoru X Pu Hu H Gui Xin X Li Tianming T Xu Jie J Li Jiao J Jia Song S Lu Dongdong D
Journal of cellular and molecular medicine 20200206 5
Several microRNAs are associated with carcinogenesis and tumour progression. Herein, our observations suggest both miR24-2 and Pim1 are up-regulated in human liver cancers, and miR24-2 accelerates growth of liver cancer cells in vitro and in vivo. Mechanistically, miR24-2 increases the expression of N6-adenosine-methyltransferase METTL3 and thereafter promotes the expression of miR6079 via RNA methylation modification. Furthermore, miR6079 targets JMJD2A and then increased the tri-methylation of ...[more]