Dataset Information

Dissolution of Silver Nanoparticles in Colloidal Consumer Products: Effects of Particle Size and Capping Agent.

ABSTRACT: The utilization of silver nanoparticles (AgNPs) in consumer products has significantly increased in recent years, primarily due to their antimicrobial properties. Increased use of AgNPs has raised ecological concerns. Once released into an aquatic environment, AgNPs may undergo oxidative dissolution leading to the generation of toxic Ag+. Therefore, it is critical to investigate the ecotoxicological potential of AgNPs and determine the physicochemical parameters that control their dissolution in aquatic environments. We have investigated the dissolution trends of aqueous colloidal AgNPs in five products, marketed as dietary supplements and surface sanitizers. The dissolution trends of AgNPs in studied products were compared to the dissolution trends of AgNPs in well-characterized laboratory-synthesized nanomaterials: citrate-coated AgNPs, polyvinylpyrrolidone-coated AgNPs, and branched polyethyleneimine-coated AgNPs. The characterization of the studied AgNPs included: particle size, anion content, metal content, silver speciation, and capping agent identification. There were small differences in the dissolved masses of Ag+ between products, but we did not observe any significant differences in the dissolution trends obtained for deionized water and tap water. The decrease of the dissolved mass of Ag+ in tap water could be due to the reaction between Ag+ and Cl-, forming AgCl and affecting their dissolution. We observed a rapid initial Ag+ release and particle size decrease for all AgNP suspensions due to the desorption of Ag+ from the nanoparticles surfaces. The observed differences in dissolution trends between AgNPs in products and laboratory-synthesized AgNPs could be caused by variances in capping agent, particle size, and total AgNP surface area in suspensions.

SUBMITTER: Radwan IM

PROVIDER: S-EPMC7077831 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Dissolution of Silver Nanoparticles in Colloidal Consumer Products: Effects of Particle Size and Capping Agent.

Radwan Islam M IM Gitipour Alireza A Potter Phillip M PM Dionysiou Dionysios D DD Al-Abed Souhail R SR

Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 20190701 7

The utilization of silver nanoparticles (AgNPs) in consumer products has significantly increased in recent years, primarily due to their antimicrobial properties. Increased use of AgNPs has raised ecological concerns. Once released into an aquatic environment, AgNPs may undergo oxidative dissolution leading to the generation of toxic Ag<sup>+</sup>. Therefore, it is critical to investigate the ecotoxicological potential of AgNPs and determine the physicochemical parameters that control their dis ...[more]

PMID: 32184700

Similar Datasets

Project description:BackgroundNo systematic investigations have been conducted to assess the lung burden imposed by the chronic inhalation of silver nanoparticles (AgNPs) emitted by spray products.ObjectiveThe objective of this study was to formulate a study framework that integrates a probabilistic risk assessment scheme with a mechanistic lung burden model for the estimation of health risks associated with the long-term inhalation of AgNP-containing spray products.Materials and methodsA compartmentalized physiologically based alveolar deposition (PBAD) model was used to estimate AgNP lung burden. Dose-response relationships were established using nanotoxicity data sets obtained from rats (as a model organism). Weibull model-based thresholds of AgNP lung burden based on neutrophil-elevated inflammation bio-markers were estimated from Hill-based exposure-response relationships. Finally, the risks of lung disease posed by various AgNP-containing spray products were assessed.ResultsConservative thresholds for the prevention of pulmonary disease were estimated as follows (mean ± SE): 34 nm AgNPs (0.32±0.22 mg) and 60 nm AgNPs (1.08±0.64 mg). Our results indicate that the risk probability was ~0.5 that the hazard quotient (HQ) estimates of deodorant with a count median diameter (CMD) ≈30 nm exceeded 1. The primary risk posed by AgNPs is transferred from the interstitial region to lymph nodes. Under the condition of 50% risk probability, the 97.5 percentile of HQ for the spray products were as follows: CMD ≈30 nm (~3.4) and CMD ≈60 nm (~1.1).ConclusionOur application of the proposed risk assessment scheme to the results obtained in an in vivo animal model proved highly effective in elucidating the relationship between the characteristics of metallic NP-containing spray products and their corresponding toxicity. The integration of the proposed PBAD model with a risk assessment framework enables the rapid assessment of risk posed by spray products containing metallic NPs over various time scales.

Project description:The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Furthermore, pulmonary exposure to various engineered nanomaterials has, likewise, demonstrated the ability to exacerbate cardiac ischemia reperfusion (I/R) injury. However, the influence of particle size or capping agent remains unclear. In an effort to address these influences we explored response to 2 different size gold core nanosilver particles (AgNP) with two different capping agents at 2 different time points. We hypothesized that a pulmonary exposure to AgNP induces cardiovascular toxicity influenced by inflammation and vascular dysfunction resulting in expansion of cardiac I/R Injury that is sensitive to particle size and the capping agent.Male Sprague-Dawley rats were exposed to 200 μg of 20 or 110 nm polyvinylprryolidone (PVP) or citrate capped AgNP. One and 7 days following intratracheal instillation serum was analyzed for concentrations of selected cytokines; cardiac I/R injury and isolated coronary artery and aorta segment were assessed for constrictor responses and endothelial dependent relaxation and endothelial independent nitric oxide dependent relaxation.AgNP instillation resulted in modest increase in selected serum cytokines with elevations in IL-2, IL-18, and IL-6. Instillation resulted in a derangement of vascular responses to constrictors serotonin or phenylephrine, as well as endothelial dependent relaxations with acetylcholine or endothelial independent relaxations by sodium nitroprusside in a capping and size dependent manner. Exposure to both 20 and 110 nm AgNP resulted in exacerbation cardiac I/R injury 1 day following IT instillation independent of capping agent with 20 nm AgNP inducing marginally greater injury. Seven days following IT instillation the expansion of I/R injury persisted but the greatest injury was associated with exposure to 110 nm PVP capped AgNP resulted in nearly a two-fold larger infarct size compared to naïve.Exposure to AgNP may result in vascular dysfunction, a potentially maladaptive sensitization of the immune system to respond to a secondary insult (e.g., cardiac I/R) which may drive expansion of I/R injury at 1 and 7 days following IT instillation where the extent of injury could be correlated with capping agents and AgNP size.

Dataset Information

Dissolution of Silver Nanoparticles in Colloidal Consumer Products: Effects of Particle Size and Capping Agent.

Publications

Dissolution of Silver Nanoparticles in Colloidal Consumer Products: Effects of Particle Size and Capping Agent.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets