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A new clinical-genomic model to predict 10-year recurrence risk in primary operable breast cancer patients.


ABSTRACT: This study aimed to validate the long-term prognostic value of a new clinical-genomic model, Distant Genetic Model-Clinical Variable Model 6 (DGM-CM6), developed in Asia as a prognostic panel for all subtypes of breast cancer. We included 752 operable stage I-III breast cancer patients representing all subtypes treated from 2005 to 2014 as the validation cohort. The median follow-up was 95.8 months. The low- and high-risk patients classified by DGM-CM6 (RI-DR) had significant differences in 10-year distant recurrence-free interval (DRFI) (94.1% vs. 85.0%, P?

SUBMITTER: Huang TT 

PROVIDER: S-EPMC7078190 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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A new clinical-genomic model to predict 10-year recurrence risk in primary operable breast cancer patients.

Huang Tzu-Ting TT   Lei Lei L   Chen Ching-Hsuan Andre CA   Lu Tzu-Pin TP   Jen Chung-Wen CW   Cheng Skye Hung-Chun SH  

Scientific reports 20200317 1


This study aimed to validate the long-term prognostic value of a new clinical-genomic model, Distant Genetic Model-Clinical Variable Model 6 (DGM-CM6), developed in Asia as a prognostic panel for all subtypes of breast cancer. We included 752 operable stage I-III breast cancer patients representing all subtypes treated from 2005 to 2014 as the validation cohort. The median follow-up was 95.8 months. The low- and high-risk patients classified by DGM-CM6 (RI-DR) had significant differences in 10-y  ...[more]

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