Ontology highlight
ABSTRACT:
SUBMITTER: Ramentol R
PROVIDER: S-EPMC7078272 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Ramentol Rosamary R Perez Marta E ME Larsson H Peter HP
Nature communications 20200317 1
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain, and mutations in HCN channels are linked to heart arrhythmia and epilepsy. HCN channels belong to the family of voltage-gated K<sup>+</sup> (Kv) channels. However, why HCN channels are activated by hyperpolarization whereas Kv channels are activated by depolarization is not clear. Here we reverse the voltage dependence of HCN channels by mutating only two residues locate ...[more]