Ontology highlight
ABSTRACT:
SUBMITTER: Zhao P
PROVIDER: S-EPMC7078456 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Zhao Pengxuan P Hou Xucheng X Yan Jingyue J Du Shi S Xue Yonger Y Li Wenqing W Xiang Guangya G Dong Yizhou Y
Bioactive materials 20200318 2
Lipid-like nanoparticles (LLNs) have been extensively explored for messenger RNA (mRNA) delivery in various biomedical applications. However, the long-term storage of these nanoparticles is still a challenge for their clinical translation. In this study, we investigated a series of conditions for the long-term storage of LLNs with encapsulation of mRNA. We evaluated the stability of LLNs with different concentrations of cryoprotectants (sucrose, trehalose or mannitol) under the conditions of fre ...[more]