Dataset Information

Feasibility of 4D CT simulation with synchronized intravenous contrast injection in hepatocellular carcinoma.

ABSTRACT: Background:Delivering Stereotactic Body Radiotherapy (SBRT) for Hepatocellular Carcinoma (HCC) is challenging mainly for two reasons: first, motion of the liver occurs in six degrees of freedom and, second, delineation of the tumor is difficult owing to a similar density of HCC to that of the adjoining healthy liver tissue in a non-contrast CT scan. To overcome both these challenges simultaneously, we performed a feasibility study to synchronize intravenous contrast to obtain an arterial and a delayed phase 4D CT. Materials and Methods:We included seven HCC patients of planned for SBRT. 4D CT simulation was performed with synchronized intravenous contrast based on the formula TSCAN DELAY?=?T peak - (L0/Detector Coverage?×?Cine Duration in Seconds). This was followed by a delayed 4D CT scan. Results:We found that, with our protocol, it is feasible to obtain a 4DCT with an arterial and a delayed phase making it comparable to a diagnostic multi-phase CT. The peak HU of the 4D scan and diagnostic CT were similar (mean peak HU 134.2 vs 143.1, p value?=?0.58?N.S). Whereas in comparison with a non-contrast CT a significant rise in the peak HU was seen (mean peak 134.2 vs 61.4 p value?=?.00003). Conclusion:A synchronized contrast 4D CT simulation for HCC is safe and feasible. It results in good contrast enhancement comparable to a diagnostic 3D contrast CT scan.

SUBMITTER: Gupta A

PROVIDER: S-EPMC7078516 | biostudies-literature | 2020 Mar-Apr

REPOSITORIES: biostudies-literature

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Feasibility of 4D CT simulation with synchronized intravenous contrast injection in hepatocellular carcinoma.

Gupta Anil A Kumar Rishabh R Yadav Hanuman Prasad HP Sharma Manik M Kamal Rose R Thaper Deepak D Banik Prabir P Gupta Shipra S Saroha Kartik K Singh Sandeep S Kumar Sarin Shiv S

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology 20191213 2

<h4>Background</h4>Delivering Stereotactic Body Radiotherapy (SBRT) for Hepatocellular Carcinoma (HCC) is challenging mainly for two reasons: first, motion of the liver occurs in six degrees of freedom and, second, delineation of the tumor is difficult owing to a similar density of HCC to that of the adjoining healthy liver tissue in a non-contrast CT scan. To overcome both these challenges simultaneously, we performed a feasibility study to synchronize intravenous contrast to obtain an arterial ...[more]

PMID: 32194348

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Feasibility of 4D CT simulation with synchronized intravenous contrast injection in hepatocellular carcinoma.

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Feasibility of 4D CT simulation with synchronized intravenous contrast injection in hepatocellular carcinoma.

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