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ABSTRACT: Background
Solar radiation causes skin damage through the generation of reactive oxygen species (ROS). While UV filters effectively reduce UV-induced ROS, they cannot prevent VIS-induced (400-760 nm) oxidative stress. Therefore, potent antioxidants are needed as additives to sunscreen products.Methods
We investigated VIS-induced ROS formation and the photoprotective effects of the Nrf2 inducer Licochalcone A (LicA).Results
Visible spectrum of 400-500 nm dose-dependently induced ROS in cultured human fibroblasts at doses equivalent to 1 hour of sunshine on a sunny summer day (150 J/cm2 ). A pretreatment for 24 hours with 1 µmol/L LicA reduced ROS formation to the level of unirradiated cells while UV filters alone were ineffective, even at SPF50+. In vivo, topical treatment with a LicA-containing SPF50 + formulation significantly prevented the depletion of intradermal carotenoids by VIS irradiation while SPF50 + control did not protect.Conclusion
LicA may be a useful additive antioxidant for sunscreens.
SUBMITTER: Mann T
PROVIDER: S-EPMC7078816 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Mann Tobias T Eggers Kerstin K Rippke Frank F Tesch Mirko M Buerger Anette A Darvin Maxim E ME Schanzer Sabine S Meinke Martina C MC Lademann Jürgen J Kolbe Ludger L
Photodermatology, photoimmunology & photomedicine 20191117 2
<h4>Background</h4>Solar radiation causes skin damage through the generation of reactive oxygen species (ROS). While UV filters effectively reduce UV-induced ROS, they cannot prevent VIS-induced (400-760 nm) oxidative stress. Therefore, potent antioxidants are needed as additives to sunscreen products.<h4>Methods</h4>We investigated VIS-induced ROS formation and the photoprotective effects of the Nrf2 inducer Licochalcone A (LicA).<h4>Results</h4>Visible spectrum of 400-500 nm dose-dependently i ...[more]