Ontology highlight
ABSTRACT:
SUBMITTER: Ewald J
PROVIDER: S-EPMC7079179 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Ewald Johannes J Blankenburg Jan J Worm Matthias M Besch Laura L Unger Ronald E RE Tremel Wolfgang W Frey Holger H Pohlit Hannah H
Chemistry (Weinheim an der Bergstrasse, Germany) 20200218 13
PEG is the gold standard polymer for pharmaceutical applications, however it lacks degradability. Degradation under physiologically relevant pH as present in endolysosomes, cancerous and inflammatory tissues is crucial for many areas. The authors present anionic ring-opening copolymerization of ethylene oxide with 3,4-epoxy-1-butene (EPB) and subsequent modification to introduce acid-degradable vinyl ether groups as well as methacrylate (MA) units, enabling radical cross-linking. Copolymers with ...[more]