Ontology highlight
ABSTRACT:
SUBMITTER: Brueckle MS
PROVIDER: S-EPMC7079360 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Brueckle Maria-Sophie MS Thomas Elizabeth T ET Seide Svenja E SE Pilz Maximilian M Gonzalez-Gonzalez Ana Isabel AI Nguyen Truc Sophia TS Harder Sebastian S Glasziou Paul P PP Gerlach Ferdinand M FM Muth Christiane C
Systematic reviews 20200317 1
<h4>Background</h4>Unwanted anticholinergic effects are both underestimated and frequently overlooked. Failure to identify adverse drug reactions (ADRs) can lead to prescribing cascades and the unnecessary use of over-the-counter products. The objective of this systematic review and meta-analysis is to explore and quantify the frequency and severity of ADRs associated with amitriptyline vs. placebo in randomized controlled trials (RCTs) involving adults with any indication, as well as healthy in ...[more]