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Naturally occurring recombination in ferret coronaviruses revealed by complete genome characterization.

ABSTRACT: Ferret coronaviruses (FRCoVs) exist as an enteric and a systemic pathotype, of which the latter is highly lethal to ferrets. To our knowledge, this study provides the first full genome sequence of a FRCoV, tentatively called FRCoV-NL-2010, which was detected in 2010 in ferrets in The Netherlands. Phylogenetic analysis showed that FRCoV-NL-2010 is most closely related to mink CoV, forming a separate clade of mustelid alphacoronavirus that split off early from other alphacoronaviruses. Based on sequence homology of the complete genome, we propose that these mustelid coronaviruses may be assigned to a new species. Comparison of FRCoV-NL-2010 with the partially sequenced ferret systemic coronavirus MSU-1 and ferret enteric coronavirus MSU-2 revealed that recombination in the spike, 3c and envelope genes occurred between different FRCoVs.

SUBMITTER: Lamers MM

PROVIDER: S-EPMC7079585 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Naturally occurring recombination in ferret coronaviruses revealed by complete genome characterization.

Lamers Mart M MM Smits Saskia L SL Hundie Gadissa B GB Provacia Lisette B LB Koopmans Marion M Osterhaus Albert D M E ADME Haagmans Bart L BL Raj V Stalin VS

The Journal of general virology 20160607 9

Ferret coronaviruses (FRCoVs) exist as an enteric and a systemic pathotype, of which the latter is highly lethal to ferrets. To our knowledge, this study provides the first full genome sequence of a FRCoV, tentatively called FRCoV-NL-2010, which was detected in 2010 in ferrets in The Netherlands. Phylogenetic analysis showed that FRCoV-NL-2010 is most closely related to mink CoV, forming a separate clade of mustelid alphacoronavirus that split off early from other alphacoronaviruses. Based on se ...[more]

PMID: 27283016

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