Ontology highlight
ABSTRACT:
SUBMITTER: Wang SJH
PROVIDER: S-EPMC7080231 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Wang Simon J H SJH Sinclair Donald A R DAR Kim Hae-Yoon HY Kinsey Stephen D SD Yoo Byoungjoo B Shih Claire R Y CRY Wong Kenneth K L KKL Krieger Charles C Harden Nicholas N Verheyen Esther M EM
PloS one 20200318 3
Homeodomain-interacting protein kinases (Hipks) have been previously associated with cell proliferation and cancer, however, their effects in the nervous system are less well understood. We have used Drosophila melanogaster to evaluate the effects of altered Hipk expression on the nervous system and muscle. Using genetic manipulation of Hipk expression we demonstrate that knockdown and over-expression of Hipk produces early adult lethality, possibly due to the effects on the nervous system and m ...[more]