Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC7080238 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Wang Wenbiao W Hu Dingwen D Wu Caifeng C Feng Yuqian Y Li Aixin A Liu Weiyong W Wang Yingchong Y Chen Keli K Tian Mingfu M Xiao Feng F Zhang Qi Q Shereen Muhammad Adnan MA Chen Weijie W Pan Pan P Wan Pin P Wu Kailang K Wu Jianguo J
PLoS pathogens 20200318 3
One of the fundamental reactions of the innate immune responses to pathogen infection is the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 inflammasome. The stimulator of interferon genes (STING) has the essential roles in innate immune response against pathogen infections. Here we reveal a distinct mechanism by which STING regulates the NLRP3 inflammasome activation, IL-1β secretion, and inflammatory responses in human cell lines, mice primary cells, and mice. I ...[more]