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Assessment of three essential tremor genetic loci in sporadic Parkinson's disease in Eastern China.

ABSTRACT: OBJECTIVE:The aim of this study was to investigate potential genetic overlap between essential tremor and Parkinson's disease in a cohort of 825 subjects from an Eastern Chinese population. METHODS:A total of 441 Parkinson's disease patients and 384 healthy controls were recruited. The MassARRAY System was used to detect three essential tremor-related single nucleotide polymorphisms. Odds ratio (OR) and 95% confidential interval (CI) were calculated to assess the relationship between polymorphisms and Parkinson's disease susceptibility. RESULTS:Our results demonstrated that the odds ratios of rs3794087 of SLC1A2, rs9652490 of LINGO1, and rs17590046 of PPARGC1A were 0.71 (95% CI = 0.55-0.91), 0.99 (95% CI = 0.78-1.26), and 0.88 (95% CI = 0.62-1.25), respectively. CONCLUSION:An essential tremor SNP (rs3794087 of SLC1A2) is associated with a decreased risk of PD in the Eastern Han Chinese population, while rs9652490 (LINGO1) and rs17590046 (PPARGC1A) do not show an association.

SUBMITTER: Gao T 

PROVIDER: S-EPMC7080431 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Assessment of three essential tremor genetic loci in sporadic Parkinson's disease in Eastern China.

Gao Ting T   Wu Jiong J   Zheng Ran R   Fang Yi Y   Jin Chong-Yao CY   Ruan Yang Y   Cao Jin J   Tian Jun J   Pu Jia-Li JL   Zhang Bao-Rong BR  

CNS neuroscience & therapeutics 20191121 4

<h4>Objective</h4>The aim of this study was to investigate potential genetic overlap between essential tremor and Parkinson's disease in a cohort of 825 subjects from an Eastern Chinese population.<h4>Methods</h4>A total of 441 Parkinson's disease patients and 384 healthy controls were recruited. The MassARRAY System was used to detect three essential tremor-related single nucleotide polymorphisms. Odds ratio (OR) and 95% confidential interval (CI) were calculated to assess the relationship betw  ...[more]

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