TRPC1 participates in the HSV-1 infection process by facilitating viral entry.
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ABSTRACT:
SUBMITTER: He D
PROVIDER: S-EPMC7080438 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
TRPC1 participates in the HSV-1 infection process by facilitating viral entry.
He DongXu D Mao AiQin A Li YouRan Y Tam SiuCheung S Zheng YongTang Y Yao XiaoQiang X Birnbaumer Lutz L Ambudkar Indu S IS Ma Xin X
Science advances 20200318 12
Mammalian transient receptor potential (TRP) channels are major components of Ca<sup>2+</sup> signaling pathways and control a diversity of physiological functions. Here, we report a specific role for TRPC1 in the entry of herpes simplex virus type 1 (HSV-1) into cells. HSV-1-induced Ca<sup>2+</sup> release and entry were dependent on Orai1, STIM1, and TRPC1. Inhibition of Ca<sup>2+</sup> entry or knockdown of these proteins attenuated viral entry and infection. HSV-1 glycoprotein D interacted w ...[more]
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