Distinguishing cell phenotype using cell epigenotype.
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ABSTRACT:
SUBMITTER: Wytock TP
PROVIDER: S-EPMC7080498 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Distinguishing cell phenotype using cell epigenotype.
Wytock Thomas P TP Motter Adilson E AE
Science advances 20200318 12
The relationship between microscopic observations and macroscopic behavior is a fundamental open question in biophysical systems. Here, we develop a unified approach that-in contrast with existing methods-predicts cell type from macromolecular data even when accounting for the scale of human tissue diversity and limitations in the available data. We achieve these benefits by applying a <i>k</i>-nearest-neighbors algorithm after projecting our data onto the eigenvectors of the correlation matrix ...[more]
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