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Pre-treatment serum bicarbonate predicts for primary tumor control after stereotactic body radiation therapy in patients with localized non-small cell lung cancer.


ABSTRACT: BACKGROUND:Tumor aggressiveness and hypoxia are linked to acidosis in the tumor microenvironment (TME). We hypothesized that low pre-treatment serum bicarbonate, potentially correlating with an acidic and hypoxic TME, predicts for poor outcomes after stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC). METHODS:We included patients with localized NSCLC treated to a biologically effective dose (BED)???100?Gy, with available pre-treatment bicarbonate values within 3?months of treatment. We used receiver operating characteristic analysis to determine the bicarbonate concentration optimally predicting for primary tumor recurrence, and evaluated its association with recurrence and survival. We validated our findings in an independent cohort of patients from three collaborating institutions. RESULTS:A total of 110 patients and 114 tumors were included in the training cohort, with median follow-up of 15.0?months. Bicarbonate?

SUBMITTER: Sebastian N 

PROVIDER: S-EPMC7080525 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Pre-treatment serum bicarbonate predicts for primary tumor control after stereotactic body radiation therapy in patients with localized non-small cell lung cancer.

Sebastian Nikhil N   Wu Trudy T   Driscoll Erin E   Willers Henning H   Kelly Suzanne S   Musunuru Hima Bindu HB   Mo Xiaokui X   Tan Yubo Y   Bazan Jose J   Haglund Karl K   Xu-Welliver Meng M   Baschnagel Andrew M AM   Ju Andrew A   Keane Florence F   Williams Terence M TM  

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20190605


<h4>Background</h4>Tumor aggressiveness and hypoxia are linked to acidosis in the tumor microenvironment (TME). We hypothesized that low pre-treatment serum bicarbonate, potentially correlating with an acidic and hypoxic TME, predicts for poor outcomes after stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC).<h4>Methods</h4>We included patients with localized NSCLC treated to a biologically effective dose (BED) ≥ 100 Gy, with available pre-treatment bicarbonate val  ...[more]

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