Ontology highlight
ABSTRACT:
SUBMITTER: Sebastian N
PROVIDER: S-EPMC7080525 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Sebastian Nikhil N Wu Trudy T Driscoll Erin E Willers Henning H Kelly Suzanne S Musunuru Hima Bindu HB Mo Xiaokui X Tan Yubo Y Bazan Jose J Haglund Karl K Xu-Welliver Meng M Baschnagel Andrew M AM Ju Andrew A Keane Florence F Williams Terence M TM
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20190605
<h4>Background</h4>Tumor aggressiveness and hypoxia are linked to acidosis in the tumor microenvironment (TME). We hypothesized that low pre-treatment serum bicarbonate, potentially correlating with an acidic and hypoxic TME, predicts for poor outcomes after stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC).<h4>Methods</h4>We included patients with localized NSCLC treated to a biologically effective dose (BED) ≥ 100 Gy, with available pre-treatment bicarbonate val ...[more]