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Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites.

ABSTRACT: There is growing evidence that oxysterols are more than simple metabolites in the pathway from cholesterol to bile acids. Recent data has shown oxysterols to be ligands to nuclear receptors and to G protein-coupled receptors, modulators of N-methyl-d-aspartate receptors and regulators of cholesterol biosynthesis. In this mini-review we will discuss the biosynthetic mechanisms for the formation of different oxysterols and the implication of disruption of these mechanisms in health and disease.

SUBMITTER: Griffiths WJ

PROVIDER: S-EPMC7081179 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites.

Griffiths William J WJ Wang Yuqin Y

Prostaglandins & other lipid mediators 20191104

There is growing evidence that oxysterols are more than simple metabolites in the pathway from cholesterol to bile acids. Recent data has shown oxysterols to be ligands to nuclear receptors and to G protein-coupled receptors, modulators of N-methyl-d-aspartate receptors and regulators of cholesterol biosynthesis. In this mini-review we will discuss the biosynthetic mechanisms for the formation of different oxysterols and the implication of disruption of these mechanisms in health and disease. ...[more]

PMID: 31698146

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