FAM13A affects body fat distribution and adipocyte function.
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ABSTRACT:
SUBMITTER: Fathzadeh M
PROVIDER: S-EPMC7081215 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
FAM13A affects body fat distribution and adipocyte function.
Fathzadeh Mohsen M Li Jiehan J Rao Abhiram A Cook Naomi N Chennamsetty Indumathi I Seldin Marcus M Zhou Xiang X Sangwung Panjamaporn P Gloudemans Michael J MJ Keller Mark M Attie Allan A Yang Jing J Wabitsch Martin M Carcamo-Orive Ivan I Tada Yuko Y Lusis Aldons J AJ Shin Myung Kyun MK Molony Cliona M CM McLaughlin Tracey T Reaven Gerald G Montgomery Stephen B SB Reilly Dermot D Quertermous Thomas T Ingelsson Erik E Knowles Joshua W JW
Nature communications 20200319 1
Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of FAM13A i ...[more]
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