Ontology highlight
ABSTRACT:
SUBMITTER: Prokopenko D
PROVIDER: S-EPMC7081222 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Prokopenko Dmitry D Hecker Julian J Kirchner Rory R Chapman Brad A BA Hoffman Oliver O Mullin Kristina K Hide Winston W Bertram Lars L Laird Nan N DeMeo Dawn L DL Lange Christoph C Tanzi Rudolph E RE
Scientific reports 20200319 1
With the advent of whole genome-sequencing (WGS) studies, family-based designs enable sex-specific analysis approaches that can be applied to only affected individuals; tests using family-based designs are attractive because they are completely robust against the effects of population substructure. These advantages make family-based association tests (FBATs) that use siblings as well as parents especially suited for the analysis of late-onset diseases such as Alzheimer's Disease (AD). However, t ...[more]